<?xml version="1.0" encoding="us-ascii"?>
<!--XBRL document created with Toppan Merrill Bridge  9.6.0.116 -->
<!--Based on XBRL 2.1-->
<!--Created on: 5/12/2020 3:16:56 PM-->
<!--Modified on: 5/12/2020 3:16:56 PM-->
<schema xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns="http://www.w3.org/2001/XMLSchema" targetNamespace="http://www.tradeweb.com/20200331" elementFormDefault="qualified" xmlns:tw="http://www.tradeweb.com/20200331" xmlns:srt-types="http://fasb.org/srt-types/2019-01-31">
  <annotation>
    <appinfo>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfFinancialCondition" id="StatementConsolidatedStatementsOfFinancialCondition">
        <link:definition>00100 - Statement - Consolidated Statements of Financial Condition</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfIncome" id="StatementConsolidatedStatementsOfIncome">
        <link:definition>00200 - Statement - Consolidated Statements of Income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfIncomeCalc1" id="StatementConsolidatedStatementsOfIncomeCalc1">
        <link:definition>00200 - Statement - Consolidated Statements of Income (Calc1)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfComprehensiveIncome" id="StatementConsolidatedStatementsOfComprehensiveIncome">
        <link:definition>00300 - Statement - Consolidated Statements of Comprehensive Income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfCashFlows" id="StatementConsolidatedStatementsOfCashFlows">
        <link:definition>00500 - Statement - Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfCashFlowsParenthetical" id="StatementConsolidatedStatementsOfCashFlowsParenthetical">
        <link:definition>00505 - Statement - Consolidated Statements of Cash Flows (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIntangibleAssetsAndGoodwillFiniteLivedIntangibleAssetsDetails" id="DisclosureIntangibleAssetsAndGoodwillFiniteLivedIntangibleAssetsDetails">
        <link:definition>40403 - Disclosure - Intangible Assets and Goodwill - Finite Lived Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureNonControllingInterestsDetails" id="DisclosureNonControllingInterestsDetails">
        <link:definition>40901 - Disclosure - Non-Controlling Interests (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansPsrusSettledActivityDetails" id="DisclosureStockBasedCompensationPlansPsrusSettledActivityDetails">
        <link:definition>41002 - Disclosure - Stock-Based Compensation Plans - PSRUs-settled activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureFairValueOfFinancialInstrumentsDetails" id="DisclosureFairValueOfFinancialInstrumentsDetails">
        <link:definition>41201 - Disclosure - Fair Value of Financial Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureEarningsPerShareDetails" id="DisclosureEarningsPerShareDetails">
        <link:definition>41501 - Disclosure - Earnings Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRegulatoryCapitalRequirementsDetails" id="DisclosureRegulatoryCapitalRequirementsDetails">
        <link:definition>41601 - Disclosure - Regulatory Capital Requirements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
        <link:definition>00090 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfFinancialConditionParenthetical" id="StatementConsolidatedStatementsOfFinancialConditionParenthetical">
        <link:definition>00105 - Statement - Consolidated Statements of Financial Condition (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfChangesInEquity" id="StatementConsolidatedStatementsOfChangesInEquity">
        <link:definition>00400 - Statement - Consolidated Statements of Changes in Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/StatementConsolidatedStatementsOfChangesInEquityParenthetical" id="StatementConsolidatedStatementsOfChangesInEquityParenthetical">
        <link:definition>00405 - Statement - Consolidated Statements of Changes in Equity (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSignificantAccountingPolicies" id="DisclosureSignificantAccountingPolicies">
        <link:definition>10201 - Disclosure - Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRestrictedCash" id="DisclosureRestrictedCash">
        <link:definition>10301 - Disclosure - Restricted Cash</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIntangibleAssetsAndGoodwill" id="DisclosureIntangibleAssetsAndGoodwill">
        <link:definition>10401 - Disclosure - Intangible Assets and Goodwill</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRevenue" id="DisclosureRevenue">
        <link:definition>10501 - Disclosure - Revenue</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIncomeTaxes" id="DisclosureIncomeTaxes">
        <link:definition>10601 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlans" id="DisclosureStockBasedCompensationPlans">
        <link:definition>11001 - Disclosure - Stock-Based Compensation Plans</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRelatedPartyTransactions" id="DisclosureRelatedPartyTransactions">
        <link:definition>11101 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureFairValueOfFinancialInstruments" id="DisclosureFairValueOfFinancialInstruments">
        <link:definition>11201 - Disclosure - Fair Value of Financial Instruments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureCreditRisk" id="DisclosureCreditRisk">
        <link:definition>11301 - Disclosure - Credit Risk</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureCommitmentsAndContingencies" id="DisclosureCommitmentsAndContingencies">
        <link:definition>11401 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureEarningsPerShare" id="DisclosureEarningsPerShare">
        <link:definition>11501 - Disclosure - Earnings Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRegulatoryCapitalRequirements" id="DisclosureRegulatoryCapitalRequirements">
        <link:definition>11601 - Disclosure - Regulatory Capital Requirements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureBusinessSegmentAndGeographicInformation" id="DisclosureBusinessSegmentAndGeographicInformation">
        <link:definition>11701 - Disclosure - Business Segment and Geographic Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSignificantAccountingPoliciesPolicies" id="DisclosureSignificantAccountingPoliciesPolicies">
        <link:definition>20202 - Disclosure - Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIntangibleAssetsAndGoodwillTables" id="DisclosureIntangibleAssetsAndGoodwillTables">
        <link:definition>30403 - Disclosure - Intangible Assets and Goodwill (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRevenueTables" id="DisclosureRevenueTables">
        <link:definition>30503 - Disclosure - Revenue (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansTables" id="DisclosureStockBasedCompensationPlansTables">
        <link:definition>31003 - Disclosure - Stock-Based Compensation Plans (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRelatedPartyTransactionsTables" id="DisclosureRelatedPartyTransactionsTables">
        <link:definition>31103 - Disclosure - Related Party Transactions (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureFairValueOfFinancialInstrumentsTables" id="DisclosureFairValueOfFinancialInstrumentsTables">
        <link:definition>31203 - Disclosure - Fair Value of Financial Instruments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureEarningsPerShareTables" id="DisclosureEarningsPerShareTables">
        <link:definition>31503 - Disclosure - Earnings Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRegulatoryCapitalRequirementsTables" id="DisclosureRegulatoryCapitalRequirementsTables">
        <link:definition>31603 - Disclosure - Regulatory Capital Requirements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureBusinessSegmentAndGeographicInformationTables" id="DisclosureBusinessSegmentAndGeographicInformationTables">
        <link:definition>31703 - Disclosure - Business Segment and Geographic Information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureOrganizationDetails" id="DisclosureOrganizationDetails">
        <link:definition>40101 - Disclosure - Organization (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSignificantAccountingPoliciesPushdownAccountingDetails" id="DisclosureSignificantAccountingPoliciesPushdownAccountingDetails">
        <link:definition>40201 - Disclosure - Significant Accounting Policies - Pushdown Accounting (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSignificantAccountingPoliciesUsefulLivesOfAssetsDetails" id="DisclosureSignificantAccountingPoliciesUsefulLivesOfAssetsDetails">
        <link:definition>40202 - Disclosure - Significant Accounting Policies - Useful Lives of Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSignificantAccountingPoliciesUsefulLivesOfIntangibleAssetsDetails" id="DisclosureSignificantAccountingPoliciesUsefulLivesOfIntangibleAssetsDetails">
        <link:definition>40203 - Disclosure - Significant Accounting Policies - Useful Lives of Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSignificantAccountingPoliciesDeferredIpoCostAndDeferredTaxAssetsCorrectionDetails" id="DisclosureSignificantAccountingPoliciesDeferredIpoCostAndDeferredTaxAssetsCorrectionDetails">
        <link:definition>40204 - Disclosure - Significant Accounting Policies - Deferred IPO Cost and Deferred Tax Assets Correction (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSignificantAccountingPoliciesStockBasedCompensationDetails" id="DisclosureSignificantAccountingPoliciesStockBasedCompensationDetails">
        <link:definition>40205 - Disclosure - Significant Accounting Policies - Stock-Based Compensation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSignificantAccountingPoliciesRecentAccountingPronouncementsDetails" id="DisclosureSignificantAccountingPoliciesRecentAccountingPronouncementsDetails">
        <link:definition>40206 - Disclosure - Significant Accounting Policies - Recent Accounting Pronouncements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRestrictedCashDetails" id="DisclosureRestrictedCashDetails">
        <link:definition>40301 - Disclosure - Restricted Cash (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIntangibleAssetsAndGoodwillSummaryOfGoodwillDetails" id="DisclosureIntangibleAssetsAndGoodwillSummaryOfGoodwillDetails">
        <link:definition>40401 - Disclosure - Intangible Assets and Goodwill - Summary of Goodwill (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIntangibleAssetsAndGoodwillIndefiniteLivedIntangibleAssetsDetails" id="DisclosureIntangibleAssetsAndGoodwillIndefiniteLivedIntangibleAssetsDetails">
        <link:definition>40402 - Disclosure - Intangible Assets and Goodwill - Indefinite Lived Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIntangibleAssetsAndGoodwillFutureAmortizationDetails" id="DisclosureIntangibleAssetsAndGoodwillFutureAmortizationDetails">
        <link:definition>40404 - Disclosure - Intangible Assets and Goodwill - Future Amortization (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRevenueBreakdownOfRevenuesBetweenFixedAndVariableDetails" id="DisclosureRevenueBreakdownOfRevenuesBetweenFixedAndVariableDetails">
        <link:definition>40501 - Disclosure - Revenue - Breakdown of Revenues Between Fixed and Variable (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRevenueDetails" id="DisclosureRevenueDetails">
        <link:definition>40502 - Disclosure - Revenue (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIncomeTaxesDetails" id="DisclosureIncomeTaxesDetails">
        <link:definition>40601 - Disclosure - Income Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityDetails" id="DisclosureStockholderSEquityDetails">
        <link:definition>40801 - Disclosure - Stockholder's Equity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityAuthorizedSharesDetails" id="DisclosureStockholderSEquityAuthorizedSharesDetails">
        <link:definition>40802 - Disclosure - Stockholder's Equity - Authorized shares (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityCommonUnitsOutstandingDetails" id="DisclosureStockholderSEquityCommonUnitsOutstandingDetails">
        <link:definition>40803 - Disclosure - Stockholder's Equity - Common Units Outstanding (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityIssuanceAndCancellationOfCommonStockDetails" id="DisclosureStockholderSEquityIssuanceAndCancellationOfCommonStockDetails">
        <link:definition>40804 - Disclosure - Stockholder's Equity - Issuance and Cancellation of Common Stock (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityRedemptionsAndExchangeOfLlcInterestsDetails" id="DisclosureStockholderSEquityRedemptionsAndExchangeOfLlcInterestsDetails">
        <link:definition>40805 - Disclosure - Stockholder's Equity - Redemptions and Exchange of LLC Interests (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansDetails" id="DisclosureStockBasedCompensationPlansDetails">
        <link:definition>41001 - Disclosure - Stock-Based Compensation Plans (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansOptionsDetails" id="DisclosureStockBasedCompensationPlansOptionsDetails">
        <link:definition>41003 - Disclosure - Stock-Based Compensation Plans - Options (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRelatedPartyTransactionsBalancesDetails" id="DisclosureRelatedPartyTransactionsBalancesDetails">
        <link:definition>41101 - Disclosure - Related Party Transactions - Balances (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRelatedPartyTransactionsConsolidatedStatementsOfIncomeDetails" id="DisclosureRelatedPartyTransactionsConsolidatedStatementsOfIncomeDetails">
        <link:definition>41102 - Disclosure - Related Party Transactions - Consolidated Statements of Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRelatedPartyTransactionsNarrativeDetails" id="DisclosureRelatedPartyTransactionsNarrativeDetails">
        <link:definition>41103 - Disclosure - Related Party Transactions - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureCreditRiskDetails" id="DisclosureCreditRiskDetails">
        <link:definition>41301 - Disclosure - Credit Risk (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureCreditRiskCreditLossesDetails" id="DisclosureCreditRiskCreditLossesDetails">
        <link:definition>41302 - Disclosure - Credit Risk - Credit losses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureCommitmentsAndContingenciesDetails" id="DisclosureCommitmentsAndContingenciesDetails">
        <link:definition>41401 - Disclosure - Commitments and Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureBusinessSegmentAndGeographicInformationRevenueByClientSectorDetails" id="DisclosureBusinessSegmentAndGeographicInformationRevenueByClientSectorDetails">
        <link:definition>41701 - Disclosure - Business Segment and Geographic Information - Revenue by Client Sector (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureBusinessSegmentAndGeographicInformationRevenueAndLongLivedAssetsByGeographicRegionDetails" id="DisclosureBusinessSegmentAndGeographicInformationRevenueAndLongLivedAssetsByGeographicRegionDetails">
        <link:definition>41702 - Disclosure - Business Segment and Geographic Information - Revenue and Long-lived Assets by Geographic Region (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSubsequentEventsDetails" id="DisclosureSubsequentEventsDetails">
        <link:definition>41801 - Disclosure - Subsequent Events (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureOrganization" id="DisclosureOrganization">
        <link:definition>10101 - Disclosure - Organization</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureTaxReceivableAgreement" id="DisclosureTaxReceivableAgreement">
        <link:definition>10701 - Disclosure - Tax Receivable Agreement</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquity" id="DisclosureStockholderSEquity">
        <link:definition>10801 - Disclosure - Stockholder's Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureNonControllingInterests" id="DisclosureNonControllingInterests">
        <link:definition>10901 - Disclosure - Non-Controlling Interests</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSubsequentEvents" id="DisclosureSubsequentEvents">
        <link:definition>11801 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholdersEquityTables" id="DisclosureStockholdersEquityTables">
        <link:definition>30803 - Disclosure - Stockholders&#x2019; Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureNonControllingInterestsTables" id="DisclosureNonControllingInterestsTables">
        <link:definition>30903 - Disclosure - Non-Controlling Interests (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureCreditRiskTables" id="DisclosureCreditRiskTables">
        <link:definition>31301 - Disclosure - Credit Risk (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureTaxReceivableAgreementDetails" id="DisclosureTaxReceivableAgreementDetails">
        <link:definition>40701 - Disclosure - Tax Receivable Agreement (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:type="simple" xlink:href="tw-20200331_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="tw-20200331_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="tw-20200331_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="tw-20200331_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links, all" />
    </appinfo>
  </annotation>
  <import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
  <import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
  <import namespace="http://xbrl.sec.gov/dei/2019-01-31" schemaLocation="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd" />
  <import namespace="http://fasb.org/us-roles/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-roles-2019-01-31.xsd" />
  <import namespace="http://fasb.org/us-gaap/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd" />
  <import namespace="http://fasb.org/srt/2019-01-31" schemaLocation="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd" />
  <import namespace="http://xbrl.sec.gov/country/2017-01-31" schemaLocation="https://xbrl.sec.gov/country/2017/country-2017-01-31.xsd" />
  <element name="DocumentAndEntityInformationAbstract" id="tw_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element id="tw_TradewebMarketsLlcMember" name="TradewebMarketsLlcMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_EquityCompensationPayable" name="EquityCompensationPayable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="tw_OtherAssetsRelatedParties" name="OtherAssetsRelatedParties" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="tw_FurnitureEquipmentAndPurchasedSoftwareMember" name="FurnitureEquipmentAndPurchasedSoftwareMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_AmortizationPeriodPushdownAccountingAdjustment" name="AmortizationPeriodPushdownAccountingAdjustment" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_TransactionFeeRevenueMember" name="TransactionFeeRevenueMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_SubscriptionFeeAndMarketDataRevenueMember" name="SubscriptionFeeAndMarketDataRevenueMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_CommissionsRevenueMember" name="CommissionsRevenueMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_VariablePricingMember" name="VariablePricingMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_RefinitivMember" name="RefinitivMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_IncomeTaxDisclosureTable" name="IncomeTaxDisclosureTable" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" xbrli:periodType="duration" />
  <element id="tw_IncomeTaxDisclosureLineItems" name="IncomeTaxDisclosureLineItems" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_CommonClassPaSharesMember" name="CommonClassPaSharesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_CommonClassPcSharesMember" name="CommonClassPcSharesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_CommonClassP1aSharesMember" name="CommonClassP1aSharesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_CommonClassP1cSharesMember" name="CommonClassP1cSharesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_SubscriptionFeeRevenueMember" name="SubscriptionFeeRevenueMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_MarketDataRevenueMember" name="MarketDataRevenueMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_IncreaseDecreaseInEquityCompensationPayable" name="IncreaseDecreaseInEquityCompensationPayable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tw_StockContributedDuringPeriodAcquireeMajorityOwner" name="StockContributedDuringPeriodAcquireeMajorityOwner" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_CommonClassCAndOrClassDMember" name="CommonClassCAndOrClassDMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_CommonClassDMember" name="CommonClassDMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_AdjustedForRefinitivTransactionMember" name="AdjustedForRefinitivTransactionMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_PerformanceSharesSettledWithCashMember" name="PerformanceSharesSettledWithCashMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_PerformanceSharesSettledWithEquityMember" name="PerformanceSharesSettledWithEquityMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_ShareBasedCompensationArrangementsByShareBasedPaymentAwardExercisePeriodFollowingChangeInControl" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardExercisePeriodFollowingChangeInControl" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_OperatingExpenseReimbursementMember" name="OperatingExpenseReimbursementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_RegulatoryCapitalRequirementsTextBlock" name="RegulatoryCapitalRequirementsTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_ScheduleOfRegulatoryCapitalRequirementsTableTextBlock" name="ScheduleOfRegulatoryCapitalRequirementsTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_TradewebLlcMember" name="TradewebLlcMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_DealerwebMember" name="DealerwebMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TradewebDirectLlcMember" name="TradewebDirectLlcMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TradewebEuropeLimitedMember" name="TradewebEuropeLimitedMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TradewebJapanKkMember" name="TradewebJapanKkMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TradewebEuBvMember" name="TradewebEuBvMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TwSefLlcMember" name="TwSefLlcMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_DwSefLlcMember" name="DwSefLlcMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_LiquidFinancialAssets" name="LiquidFinancialAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="tw_ExcessLiquidFinancialAssets" name="ExcessLiquidFinancialAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="tw_RequiredLiquidFinancialAssets" name="RequiredLiquidFinancialAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="tw_InstitutionalClientSectorMember" name="InstitutionalClientSectorMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_WholesaleClientSectorMember" name="WholesaleClientSectorMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_RetailClientSectorMember" name="RetailClientSectorMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_MarketDataClientSectorMember" name="MarketDataClientSectorMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_ContractWithCustomerLiabilityNewBillings" name="ContractWithCustomerLiabilityNewBillings" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tw_ScheduleOfCashSettledPerformanceBasedUnitsActivityTableTextBlock" name="ScheduleOfCashSettledPerformanceBasedUnitsActivityTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_CommonStockSharesCanceled" name="CommonStockSharesCanceled" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_VotingPowerThresholdPercentageToRequireConversionOfShares" name="VotingPowerThresholdPercentageToRequireConversionOfShares" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <element id="tw_ContractWithCustomerLiabilityRelatedParties" name="ContractWithCustomerLiabilityRelatedParties" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="tw_ContinuingLLCOwnersMember" name="ContinuingLLCOwnersMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_RegulatoryCapital" name="RegulatoryCapital" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="tw_RegulatoryCapitalRequirement" name="RegulatoryCapitalRequirement" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="tw_ExcessRegulatoryCapital" name="ExcessRegulatoryCapital" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="tw_TaxReceivableAgreementLiability" name="TaxReceivableAgreementLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="tw_NetIncomeLossAttributableToLimitedLiabilityCompany" name="NetIncomeLossAttributableToLimitedLiabilityCompany" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tw_PaymentsOfCapitalDistributionToNoncontrollingInterest" name="PaymentsOfCapitalDistributionToNoncontrollingInterest" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tw_TaxReceivableAgreementLiabilityAbstract" name="TaxReceivableAgreementLiabilityAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TaxReceivableAgreementLiabilityDisclosureTextBlock" name="TaxReceivableAgreementLiabilityDisclosureTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_TaxReceivableAgreementPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" name="TaxReceivableAgreementPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_AccountsPayableAccruedExpensesAndOtherLiabilitiesMember" name="AccountsPayableAccruedExpensesAndOtherLiabilitiesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_ScheduleOfImpactOnEquityDueToChangesInCompanysOwnershipInterestInNoncontrollingInterestTableTextBlock" name="ScheduleOfImpactOnEquityDueToChangesInCompanysOwnershipInterestInNoncontrollingInterestTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_MinorityInterestTotalOwnershipPercentage" name="MinorityInterestTotalOwnershipPercentage" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <element id="tw_NoncontrollingInterestConversionRatio" name="NoncontrollingInterestConversionRatio" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_NetIncomeAttributableToParentAndTransfersToFromNoncontrollingInterest" name="NetIncomeAttributableToParentAndTransfersToFromNoncontrollingInterest" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tw_EquitySettledPerformanceBasedRestrictedStockUnitsMember" name="EquitySettledPerformanceBasedRestrictedStockUnitsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_NumberOfVotesPerCommonStock" name="NumberOfVotesPerCommonStock" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_CommonStockConversionRatio" name="CommonStockConversionRatio" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_ThresholdPercentageOfEconomicInterestForConversion" name="ThresholdPercentageOfEconomicInterestForConversion" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_CommonStockCancellationRatio" name="CommonStockCancellationRatio" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_ScheduleOfCommonUnitsOutstandingTableTextBlock" name="ScheduleOfCommonUnitsOutstandingTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_CommonUnitExchangedNumber" name="CommonUnitExchangedNumber" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_LlcInterestsMember" name="LlcInterestsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_AdjustmentsToAdditionalPaidInCapitalTaxReceivableAgreementLiabilityAndDeferredTaxesReorganizationTransactionAndIpo" name="AdjustmentsToAdditionalPaidInCapitalTaxReceivableAgreementLiabilityAndDeferredTaxesReorganizationTransactionAndIpo" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tw_MinorityInterestIncreaseDecreaseFromAdjustments" name="MinorityInterestIncreaseDecreaseFromAdjustments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tw_ScheduleOfOwnershipInterestInNoncontrollingInterestTableTextBlock" name="ScheduleOfOwnershipInterestInNoncontrollingInterestTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_ScheduleOfRelatedPartyTransactionsAffiliatesTableTextBlock" name="ScheduleOfRelatedPartyTransactionsAffiliatesTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_MinorityInterestNumberOfInterestsHeldByParent" name="MinorityInterestNumberOfInterestsHeldByParent" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_MinorityInterestNumberOfInterestsHeldByNoncontrollingOwners" name="MinorityInterestNumberOfInterestsHeldByNoncontrollingOwners" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_MinorityInterestTotalNumberOfInterests" name="MinorityInterestTotalNumberOfInterests" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_OneMonthLondonInterBankOfferedRateMember" name="OneMonthLondonInterBankOfferedRateMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_DebtInstrumentFloorRate" name="DebtInstrumentFloorRate" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_TaxReceivableAgreementRemainingPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" name="TaxReceivableAgreementRemainingPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_RefinitivDirectOwnerMember" name="RefinitivDirectOwnerMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_RefinitivLlcOwnerMember" name="RefinitivLlcOwnerMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_PercentageOfCombinedVotingPowerOfCommonStock" name="PercentageOfCombinedVotingPowerOfCommonStock" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_PercentageOfEconomicInterestInLimitedLiabilityCompany" name="PercentageOfEconomicInterestInLimitedLiabilityCompany" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_ProfitLossAfterPreIpo" name="ProfitLossAfterPreIpo" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tw_PotentialDilutiveSecuritiesMember" name="PotentialDilutiveSecuritiesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_StockCompensationExpenseAllocationTerm" name="StockCompensationExpenseAllocationTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_AccountReceivableExcludingReceivableFromBrokersAndDealersAndClearingOrganizationsNetOfAllowance" name="AccountReceivableExcludingReceivableFromBrokersAndDealersAndClearingOrganizationsNetOfAllowance" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="tw_FollowOnOfferingMember" name="FollowOnOfferingMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TradeWebMarketsLlcMember" name="TradeWebMarketsLlcMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TransfersFromToNoncontrollingInterests" name="TransfersFromToNoncontrollingInterests" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="tw_SharedServicesFeesAbstract" name="SharedServicesFeesAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_TradewebMarketsIncMember" name="TradewebMarketsIncMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_LimitedLiabilityCompanyUnitsMember" name="LimitedLiabilityCompanyUnitsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_PercentageOfPerformanceModifier" name="PercentageOfPerformanceModifier" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_DepositsWithClearingOrganizations" name="DepositsWithClearingOrganizations" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_OctoberTwoThousandNineteenFollowOnOfferingMember" name="OctoberTwoThousandNineteenFollowOnOfferingMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_RedemptionsAndExchangesOfLlcInterestsMember" name="RedemptionsAndExchangesOfLlcInterestsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_NumberOfLlcUnitsReceived" name="NumberOfLlcUnitsReceived" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="tw_PublicInvestorsMember" name="PublicInvestorsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_BankStockholdersMember" name="BankStockholdersMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="tw_NumberOfShareOwned" name="NumberOfShareOwned" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <element id="tw_VotingPowerPercentage" name="VotingPowerPercentage" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <element id="tw_LeaseholdInterest" name="LeaseholdInterest" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="tw_ConsultingServiceFeeForIpo" name="ConsultingServiceFeeForIpo" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tw_ConsultingServiceFeeForFollowOnOffering" name="ConsultingServiceFeeForFollowOnOffering" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tw_AdjustmentToAdditionalPaidInCapitalDueToConsultingServiceFee" name="AdjustmentToAdditionalPaidInCapitalDueToConsultingServiceFee" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="tw_Omnibus2019EquityIncentivePlanMember" name="Omnibus2019EquityIncentivePlanMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
</schema>
