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        <link:definition>40206 - Disclosure - Significant Accounting Policies - Recent Accounting Pronouncements (Details)</link:definition>
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        <link:definition>40401 - Disclosure - Intangible Assets and Goodwill - Indefinite Lived Intangible Assets (Details)</link:definition>
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        <link:definition>40403 - Disclosure - Intangible Assets and Goodwill - Future Amortization (Details)</link:definition>
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        <link:definition>40501 - Disclosure - Leases (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRestrictedCashDetails" id="DisclosureRestrictedCashDetails">
        <link:definition>40601 - Disclosure - Restricted Cash (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>40701 - Disclosure - Deferred Revenue (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>40901 - Disclosure - Income Taxes - Income (loss) before provision for tax (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureIncomeTaxesNarrativeDetails" id="DisclosureIncomeTaxesNarrativeDetails">
        <link:definition>40907 - Disclosure - Income Taxes - Narrative (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityDetails" id="DisclosureStockholderSEquityDetails">
        <link:definition>41101 - Disclosure - Stockholder's Equity (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityAuthorizedSharesDetails" id="DisclosureStockholderSEquityAuthorizedSharesDetails">
        <link:definition>41102 - Disclosure - Stockholder's Equity - Authorized shares (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityCommonUnitsOutstandingDetails" id="DisclosureStockholderSEquityCommonUnitsOutstandingDetails">
        <link:definition>41103 - Disclosure - Stockholder's Equity - Common Units Outstanding (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>41104 - Disclosure - Stockholder's Equity - Issuance and Cancellation of Common Stock (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquityRedemptionsAndExchangeOfLlcInterestsDetails" id="DisclosureStockholderSEquityRedemptionsAndExchangeOfLlcInterestsDetails">
        <link:definition>41105 - Disclosure - Stockholder's Equity - Redemptions and Exchange of LLC Interests (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansDetails" id="DisclosureStockBasedCompensationPlansDetails">
        <link:definition>41301 - Disclosure - Stock-Based Compensation Plans (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansPrsusSettlementDetails" id="DisclosureStockBasedCompensationPlansPrsusSettlementDetails">
        <link:definition>41302 - Disclosure - Stock-Based Compensation Plans - (PRSUs settlement) (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansOptionsDetails" id="DisclosureStockBasedCompensationPlansOptionsDetails">
        <link:definition>41304 - Disclosure - Stock-Based Compensation Plans - Options (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansCompensationExpenseDetails" id="DisclosureStockBasedCompensationPlansCompensationExpenseDetails">
        <link:definition>41306 - Disclosure - Stock-Based Compensation Plans - Compensation expense (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockBasedCompensationPlansUnrecognizedCompensationExpenseDetails" id="DisclosureStockBasedCompensationPlansUnrecognizedCompensationExpenseDetails">
        <link:definition>41307 - Disclosure - Stock-Based Compensation Plans - unrecognized compensation expense (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRelatedPartyTransactionsBalancesDetails" id="DisclosureRelatedPartyTransactionsBalancesDetails">
        <link:definition>41401 - Disclosure - Related Party Transactions - Balances (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRelatedPartyTransactionsConsolidatedStatementsOfIncomeDetails" id="DisclosureRelatedPartyTransactionsConsolidatedStatementsOfIncomeDetails">
        <link:definition>41402 - Disclosure - Related Party Transactions - Consolidated Statements of Income (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureRelatedPartyTransactionsNarrativeDetails" id="DisclosureRelatedPartyTransactionsNarrativeDetails">
        <link:definition>41403 - Disclosure - Related Party Transactions - Narrative (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureCreditRiskDetails" id="DisclosureCreditRiskDetails">
        <link:definition>41601 - Disclosure - Credit Risk (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>41701 - Disclosure - Commitments and Contingencies (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>42001 - Disclosure - Business Segment and Geographic Information - Revenue by Client Sector (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>42002 - Disclosure - Business Segment and Geographic Information - Revenue and Long-lived Assets by Geographic Region (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>42101 - Disclosure - Quarterly Results of Operations (Unaudited) - Operating results (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureSubsequentEventsDetails" id="DisclosureSubsequentEventsDetails">
        <link:definition>42201 - Disclosure - Subsequent Events (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureOrganization" id="DisclosureOrganization">
        <link:definition>10101 - Disclosure - Organization</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureTaxReceivableAgreement" id="DisclosureTaxReceivableAgreement">
        <link:definition>11001 - Disclosure - Tax Receivable Agreement</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholderSEquity" id="DisclosureStockholderSEquity">
        <link:definition>11101 - Disclosure - Stockholder's Equity</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureNonControllingInterests" id="DisclosureNonControllingInterests">
        <link:definition>11201 - Disclosure - Non-Controlling Interests</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>12101 - Disclosure - Quarterly Results of Operations (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>12201 - Disclosure - Subsequent Events</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://www.tradeweb.com/role/DisclosureStockholdersEquityTables" id="DisclosureStockholdersEquityTables">
        <link:definition>31103 - Disclosure - Stockholders&#x2019; Equity (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>31203 - Disclosure - Non-Controlling Interests (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>40906 - Disclosure - Income Taxes - Uncertain Tax Position (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>41001 - Disclosure - Tax Receivable Agreement (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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</schema>
