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  <xs:element id="tw_PaymentsOnTaxReceivableAgreementLiability" abstract="false" name="PaymentsOnTaxReceivableAgreementLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_TaxReceivableAgreementRemainingPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" abstract="false" name="TaxReceivableAgreementRemainingPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="tw_TaxReceivableAgreementLiabilityDisclosureTextBlock" abstract="false" name="TaxReceivableAgreementLiabilityDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tw_TradewebLlcMember" abstract="true" name="TradewebLlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_OneMonthLondonInterBankOfferedRateMember" abstract="true" name="OneMonthLondonInterBankOfferedRateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_MarketDataClientSectorMember" abstract="true" name="MarketDataClientSectorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="tw_TradewebExecutionServicesBVMember" abstract="true" name="TradewebExecutionServicesBVMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="tw_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityNetOfModifications" abstract="false" name="RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityNetOfModifications" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedEmployeesRelatedLiabilities" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedEmployeesRelatedLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="tw_NumberOfVotesPerCommonStock" abstract="false" name="NumberOfVotesPerCommonStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="tw_Omnibus2019EquityIncentivePlanMember" abstract="true" name="Omnibus2019EquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_TWMLLCMember" abstract="true" name="TWMLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndAdjustmentsWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndAdjustmentsWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
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  <xs:element id="tw_ContractWithCustomerLiabilityRelatedParties" abstract="false" name="ContractWithCustomerLiabilityRelatedParties" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_ContractWithCustomerLiabilityForeignCurrencyExchangeRate" abstract="false" name="ContractWithCustomerLiabilityForeignCurrencyExchangeRate" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossShares" abstract="false" name="ParticipatingSecuritiesDistributedAndUndistributedEarningsLossShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tw_AmortizationPeriodPushdownAccountingAdjustment" abstract="false" name="AmortizationPeriodPushdownAccountingAdjustment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tw_TradewebEuropeLimitedMember" abstract="true" name="TradewebEuropeLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_DepositsWithClearingOrganizationsPolicyTextBlock" abstract="false" name="DepositsWithClearingOrganizationsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
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  <xs:element id="tw_NumberOfShareOwned" abstract="false" name="NumberOfShareOwned" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="tw_ChangeInContractWithCustomerLiabilityRollForward" abstract="true" name="ChangeInContractWithCustomerLiabilityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="tw_FurnitureEquipmentAndPurchasedSoftwareMember" abstract="true" name="FurnitureEquipmentAndPurchasedSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOtherAssets" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOtherAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="tw_TaxReceivableAgreementLiabilityAdjustment" abstract="false" name="TaxReceivableAgreementLiabilityAdjustment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_MinorityInterestNumberOfInterestsHeldByNoncontrollingOwners" abstract="false" name="MinorityInterestNumberOfInterestsHeldByNoncontrollingOwners" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="tw_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceAdjustmentInPeriodWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceAdjustmentInPeriodWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
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  <xs:element id="tw_TaxReceivableAgreementPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" abstract="false" name="TaxReceivableAgreementPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_ConsultingServiceFeeForFollowOnOffering" abstract="false" name="ConsultingServiceFeeForFollowOnOffering" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="tw_TradewebJapanKkMember" abstract="true" name="TradewebJapanKkMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_SubscriptionFeeRevenueMember" abstract="true" name="SubscriptionFeeRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="tw_PerformanceSharesSettledWithEquityMember" abstract="true" name="PerformanceSharesSettledWithEquityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpiredWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpiredWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
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  <xs:element id="tw_EquitySettledPerformanceBasedRestrictedStockUnitsMember" abstract="true" name="EquitySettledPerformanceBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="tw_ThresholdPercentageOfEconomicInterestForConversion" abstract="false" name="ThresholdPercentageOfEconomicInterestForConversion" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_DebtInstrumentFloorRate" abstract="false" name="DebtInstrumentFloorRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_ExcessRegulatoryCapital" abstract="false" name="ExcessRegulatoryCapital" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_BankStockholdersMember" abstract="true" name="BankStockholdersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="tw_MinorityInterestIncreaseDecreaseFromAdjustments" abstract="false" name="MinorityInterestIncreaseDecreaseFromAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="tw_TransactionFeeRevenueMember" abstract="true" name="TransactionFeeRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_IncreaseDecreaseInEquityCompensationPayable" abstract="false" name="IncreaseDecreaseInEquityCompensationPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="tw_A2021ShareRepurchaseProgramMember" abstract="true" name="A2021ShareRepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ContractWithCustomerLiabilityRevenueRecognizedIncludingNewBillings" abstract="false" name="ContractWithCustomerLiabilityRevenueRecognizedIncludingNewBillings" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetOfAcquiredCashAndRestrictedCashDepositsWithClearingOrganizations" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNetOfAcquiredCashAndRestrictedCashDepositsWithClearingOrganizations" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_TradeWebMarketsLlcMember" abstract="true" name="TradeWebMarketsLlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_AccountsPayableAccruedExpensesAndOtherLiabilitiesRelatedParties" abstract="false" name="AccountsPayableAccruedExpensesAndOtherLiabilitiesRelatedParties" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_ClassCAndClassDCommonStockMember" abstract="true" name="ClassCAndClassDCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_RefinitivDirectOwnerMember" abstract="true" name="RefinitivDirectOwnerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ShareBasedPaymentArrangementMultiplierAchievedAdjustmentIncreaseDecrease" abstract="false" name="ShareBasedPaymentArrangementMultiplierAchievedAdjustmentIncreaseDecrease" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="tw_SoftwareDevelopmentCostsAbstract" abstract="true" name="SoftwareDevelopmentCostsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tw_AdjustmentsToAdditionalPaidInCapitalTaxReceivableAgreementLiabilityAndDeferredTaxesReorganizationTransactionAndIpo" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalTaxReceivableAgreementLiabilityAndDeferredTaxesReorganizationTransactionAndIpo" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_FollowOnOfferingMember" abstract="true" name="FollowOnOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_StockContributedDuringPeriodAcquireeMajorityOwner" abstract="false" name="StockContributedDuringPeriodAcquireeMajorityOwner" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tw_AccountReceivableExcludingReceivableFromBrokersAndDealersAndClearingOrganizationsNetOfAllowance" abstract="false" name="AccountReceivableExcludingReceivableFromBrokersAndDealersAndClearingOrganizationsNetOfAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_RestrictedCashAndCashEquivalentsFairValueDisclosure" abstract="false" name="RestrictedCashAndCashEquivalentsFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_ScheduleOfRelatedPartyTransactionsAffiliatesTableTextBlock" abstract="false" name="ScheduleOfRelatedPartyTransactionsAffiliatesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tw_TaxReceivableAgreementLiability" abstract="false" name="TaxReceivableAgreementLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_NFIAcquisitionMember" abstract="true" name="NFIAcquisitionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ScheduleOfImpactOnEquityDueToChangesInTheCompanysOwnershipInterestInNoncontrollingInterestTableTextBlock" abstract="false" name="ScheduleOfImpactOnEquityDueToChangesInTheCompanysOwnershipInterestInNoncontrollingInterestTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tw_VotingPowerPercentage" abstract="false" name="VotingPowerPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_MinorityInterestTotalNumberOfInterests" abstract="false" name="MinorityInterestTotalNumberOfInterests" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tw_InstitutionalClientSectorMember" abstract="true" name="InstitutionalClientSectorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_TransfersFromToNoncontrollingInterests" abstract="false" name="TransfersFromToNoncontrollingInterests" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_PaymentsOfCapitalDistributionToNoncontrollingInterest" abstract="false" name="PaymentsOfCapitalDistributionToNoncontrollingInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_WholesaleClientSectorMember" abstract="true" name="WholesaleClientSectorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ContractWithCustomerLiabilityNewBillings" abstract="false" name="ContractWithCustomerLiabilityNewBillings" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_AdjustmentsToAdditionalPaidInCapitalIncomeDeferredIncomeTaxEffectFromShareRepurchases" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalIncomeDeferredIncomeTaxEffectFromShareRepurchases" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_DeferredTaxAssetsTaxReceivableAgreement" abstract="false" name="DeferredTaxAssetsTaxReceivableAgreement" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_SubscriptionFeeAndMarketDataRevenueMember" abstract="true" name="SubscriptionFeeAndMarketDataRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_MinorityInterestNumberOfInterestsHeldByParent" abstract="false" name="MinorityInterestNumberOfInterestsHeldByParent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tw_TradewebDirectLlcMember" abstract="true" name="TradewebDirectLlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_NonCapitalizedComputerSoftwareAmortization" abstract="false" name="NonCapitalizedComputerSoftwareAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
</xs:schema>
