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      <link:roleType id="BusinessSegmentandGeographicInformationRevenueandLonglivedAssetsbyGeographicRegionDetails" roleURI="http://www.tradeweb.com/role/BusinessSegmentandGeographicInformationRevenueandLonglivedAssetsbyGeographicRegionDetails">
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  <xs:element id="tw_EffectOfReorganizationTransactions" abstract="false" name="EffectOfReorganizationTransactions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_ExecutionAccessMember" abstract="true" name="ExecutionAccessMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ClassCAndClassDCommonStockMember" abstract="true" name="ClassCAndClassDCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_LocalJurisdictionMember" abstract="true" name="LocalJurisdictionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_PerformanceSharesSettledWithEquityMember" abstract="true" name="PerformanceSharesSettledWithEquityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_CommonClassPcSharesMember" abstract="true" name="CommonClassPcSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_TradewebDirectLlcMember" abstract="true" name="TradewebDirectLlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ExcessRegulatoryCapital" abstract="false" name="ExcessRegulatoryCapital" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_SecuredOperatingLeaseMember" abstract="true" name="SecuredOperatingLeaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_DwSefLlcMember" abstract="true" name="DwSefLlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_OctoberTwoThousandNineteenFollowOnOfferingMember" abstract="true" name="OctoberTwoThousandNineteenFollowOnOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_ScheduleOfRegulatoryCapitalRequirementsTableTextBlock" abstract="false" name="ScheduleOfRegulatoryCapitalRequirementsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tw_NoncontrollingInterestConversionRatio" abstract="false" name="NoncontrollingInterestConversionRatio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tw_VotingPowerThresholdPercentageToRequireConversionOfShares" abstract="false" name="VotingPowerThresholdPercentageToRequireConversionOfShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_ScheduleOfImpactOnEquityDueToChangesInTheCompanysOwnershipInterestInNoncontrollingInterestTableTextBlock" abstract="false" name="ScheduleOfImpactOnEquityDueToChangesInTheCompanysOwnershipInterestInNoncontrollingInterestTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tw_StockContributedDuringPeriodAcquireeMajorityOwner" abstract="false" name="StockContributedDuringPeriodAcquireeMajorityOwner" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tw_TaxReceivableAgreementPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" abstract="false" name="TaxReceivableAgreementPercentageOfAmountOfFederalStateAndLocalIncomeOrFranchiseTaxSavings" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_PercentageOfPerformanceModifier" abstract="false" name="PercentageOfPerformanceModifier" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndAdjustmentsWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndAdjustmentsWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tw_RegulatoryCapitalRequirementsTextBlock" abstract="false" name="RegulatoryCapitalRequirementsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tw_ScheduleOfRelatedPartyTransactionsAffiliatesTableTextBlock" abstract="false" name="ScheduleOfRelatedPartyTransactionsAffiliatesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tw_ChangeInContractWithCustomerLiabilityRollForward" abstract="true" name="ChangeInContractWithCustomerLiabilityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tw_AdjustmentToAdditionalPaidInCapitalDueToConsultingServiceFee" abstract="false" name="AdjustmentToAdditionalPaidInCapitalDueToConsultingServiceFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_DepositsWithClearingOrganizationsPolicyTextBlock" abstract="false" name="DepositsWithClearingOrganizationsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tw_RelatedPartyTransactionPayableReversal" abstract="false" name="RelatedPartyTransactionPayableReversal" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_MinorityInterestIncreaseFromAllocationOfEquity" abstract="false" name="MinorityInterestIncreaseFromAllocationOfEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_EffectiveIncomeTaxRateReconciliationEquityCompensationPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationEquityCompensationPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_ExcessLiquidFinancialAssets" abstract="false" name="ExcessLiquidFinancialAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tw_OtherStockholdersMember" abstract="true" name="OtherStockholdersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tw_PercentageOfEconomicInterestInLimitedLiabilityCompany" abstract="false" name="PercentageOfEconomicInterestInLimitedLiabilityCompany" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tw_PaymentsOfCapitalDistributionToNoncontrollingInterest" abstract="false" name="PaymentsOfCapitalDistributionToNoncontrollingInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
